1257044-40-8 venetoclax

Eiddo

Ymddangosiad golau melyn i solid melyn
Melting point:>150 gradd (dec.)
Dwysedd 1.34 0 ± 0.06 g/cm3
Temp Storio. Rhewgell gradd -20
hydoddedd DMSO (ychydig)
PKA4. 0 9 ± 0.10
 

Cais:

Venetoclax, a gymeradwywyd gan yr FDA ar Ebrill 11, 2016, yw atalydd Bcl -2 cyntaf y byd. Mae'r cyffur hwn nid yn unig y cyntaf o'i fath fel atalydd protein Bcl -2, ond hefyd y cyffur moleciwl bach cymeradwy cyntaf ym maes rhyngweithiadau protein-protein, gan farcio carreg filltir. Therapi cyfuniad ag azacitidine ar gyfer cleifion lewcemia myeloid acíwt 75 oed neu'n hŷn.

Mae gan Venetoclax affinedd uchel ar gyfer parth rhwymo BH3 o Bcl -2, a all hyrwyddo apoptosis celloedd ac atal amlhau celloedd trwy atal mynegiant uchel Bcl -2 mewn celloedd AML. Gellir defnyddio venetoclax i drin lewcemia lymffocytig cronig, lewcemia myeloid acíwt, a myeloma lluosog.

 

Cyfystyron:

Fenetoclax

1257044-40-8

Abt -199

VenclextaCity name (optional, probably does not need a translation)

GDC -0199

VenclyxtoCity name (optional, probably does not need a translation)

4- [{4- [[2- (4- clorophenyl) -4, 4- dimethylcyclohexen -1-}}}}}}}}}}}}} } nitro -4- (oxan {-4- ylmethylamino) phenyl] sulfonyl -2- (1h-pyrrolo [2, {3- b] pyridin {{18} yloxy) Benzamy)

Venetoclax (abt -199)

Abt -199 (gdc -0199)

Benzamide, 4- [4- [[2- (4- clorophenyl) -4, 4- dimethyl {{{{6 }} cyclohexen -1- yl] methyl] -1- piperazinyl] -n-[[3- nitr Nitr o -4- [[(tetrahydro {-2 H-pyran -4- yl) methyl] amino] phenyl] sulfonyl] -2- (1h-pyrrolo [2, {3- B-pyridin}}}}}}}

ABT 199 (Venetoclax)

2- (1h-pyrrolo [2, 3- b] pyridin -5- yloxy) -4- ({ {7}} ((2- (4- clorophenyl) -4, 4- dimethylc yclohex -1- enyl) methyl) piperazin -1- yl) -n-({3- nitro -4- ((tetrahydro {-2 h-pyran {20}} yl)

4- (4- ((2- (4- clorophenyl) -4, 4- dimethylcycl OHEX -1- en -1- yl) methyl) piperazin -1- yl) -n-({3- nitro {{{{{{{{{{{{{{{{{{{{{{{{{{{{ 12}} ((tetrahydro -2 H-pyran {-4- ylmethyl) amino) phenyl) sulfonyl) -2- (1h-pyrrolo (2, {3- b) pyrid

4- (4- {[2- (4- clorophenyl) -4, 4- dimethyl cyclohex -1- en -1- yl] methyl} piperazin -1- yl) -n-({{{{11 }} nitro -4- [(Oxan -4- ylmethyl) amino] bensen} sulfonyl) -2- {1h-pyrrolo [2, {3- b] pyridin}}}}}}}

 

Tagiau poblogaidd: 1257044-40-8 Venetoclax, China 1257044-40-8 Gwneuthurwyr Venetoclax, Cyflenwyr